• Contents
  • Key Takeaways
  • Source
  • Full Notes
  • Support the Podcast
4 Min Read
Last Updated: 29.05.23

The Science of Looking Younger, Longer

Sinclair and LaPlante examine cosmetic aging and methods to enhance skin, nails, and hair. They explore the connection between external signs of aging and biological age. They highlight the latest scientific advancements in beautifying therapies, such as low-​​level laser therapy and platelet-​​rich plasma injections.

Key Takeaways

High level takeaways from the episode.

Menopause affects women’s reproductive system earlier than other organs show damage from aging

Menopause symptoms: mood swings, vaginal dryness, loss of sex drive, migraines, hot flashes, increased susceptibility to heart disease

Menopausal hormone therapy can offer symptomatic relief

  • Dual use of estrogen and progesterone in the right combination, ratio, and timing is important
  • Women should measure baseline levels of estrogen and progesterone during their 30s and 40s to help physicians match those levels during menopause

Long-​​term hormone replacement therapy may protect against heart disease and bone loss

  • Consult with a physician, especially if there’s a history of breast cancer

Epidermal Thinning

  • Accelerated during and after menopause
  • Affects the skin’s appearance as it ages

Epidermal thinning a problem for aging individuals, especially women during menopause

  • Thin skin can lead to easier bruising, tearing, and infection

Foot Ulcers

  • Affect about 13% of the US population
  • Can arise from tripping or stepping on sharp objects
  • Difficult to heal, can lead to amputation and infection
  • Importance of maintaining skin health and thickness

2012 study: elderly people rated on appearance, health, attractiveness, and facial symmetry

  • Those rated as older-​​looking more likely to die within seven years
  • Suggests a correlation between appearance and biological age

Skin is full of senescent cells, which are zombie-​​like cells that stop dividing and producing

  • They secrete inflammatory factors and mitogens that stimulate cancer
  • Deleting senescent cells can lead to rejuvenation of the body, including skin

Peptides can potentially reverse skin aging by targeting senescent cells

  • One Skin is a product containing a peptide that shows efficacy in human clinical trials

Collagen is an important component of younger skin, making it more flexible and thicker

  • Collagen production decreases as we age

Retinol and vitamin C are currently more effective in protecting and rejuvenating skin

  • Retinoids boost collagen production and stimulate cell growth
  • Retinol products can cause dry skin, requiring moisturization
  • Retinols inhibit MMPs (metalloproteases) that break down the skin
  • Retinols promote keratinocyte growth, which produces keratin (important for skin, hair, and nails)

Nail growth rate can indicate biological age

Nail growth decreases about 0.5% per year

Faster nail growth may indicate slower aging

Retinol can engage in autophagy (recycling of old proteins in the cell)

Resveratrol is a weak antioxidant but may activate sirtuin activity, which has various benefits

NAD-​​boosting molecules like nicotinamide or nicotinic acid can be found in cosmetics and may have beneficial effects on the skin

HA is important for skin plumpness and flexibility

  • Found in abundance in long-​​lived organisms, potentially protecting against cancer
  • Topical HA works well as a moisturizer, but injectable HA may be more effective for improving volume loss and laxity of the skin

Botox is a toxin from the bacterium Clostridium botulinum

  • Inhibits neurotransmission, relaxing muscles and reducing wrinkles
  • Effective for wrinkle reduction but requires repeated injections every 6–9 months

Micro needling

  • May induce minor stress, hormesis, and repair factors
  • Long-​​term benefits on skin age not proven


  • Accelerates aging in the body and shows up on the skin


  • Research shows it’s bad for skin health


  • Processed foods, fats, and chemicals can affect aging and skin health

Study of 3,690 men found optimal DHT levels for longevity

  • Relatively low, but within middle range (9.8 to 15.8 nanomoles per liter)

Eunuchs tend to live longer than the general population

  • 3 out of 81 eunuchs studied became centenarians
  • 130 times greater chance of reaching 100 than the general population

Excess testosterone and growth hormone may promote aging

Low Laser Light Therapy (LLLT)

  • FDA-​​approved treatment for hair loss
  • Red laser light combs and caps
  • Clinical trials show slowed hair loss and regrowth in some people
  • Unclear how it works, but may involve nitric oxide and mitochondrial function

Platelet Rich Plasma (PRP) Injections for Hair Loss

  • Used for sports injuries and hair loss
  • Blood is taken, spun to separate platelets, and injected into the scalp
  • Contains exosomes, hormones, peptides, and possibly V cells
  • Unclear which components promote hair growth

Recent research shows graying hair can be reversible

Potential Future Treatment for Graying Hair

  • Combination of compounds, including cyclosporin A, minoxidil, and a pigment-​​promoting drug
  • Not yet ready for human use, but potential for future products

Lessons learned from reversing aging in skin and hair can be applied to other organs

  • Rapamycin, cyclosporine, and minoxidil could potentially be used in low doses for rejuvenating effects

Future possibility of taking pills to not only get younger but also regrow and darken hair


We recommend using this distillation as a supplemental resource to the source material.

Full Notes

Support the Podcast