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  • Key Takeaways
  • Protocols
  • Source
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Hormones
3 Min Read
Last Updated: 13.06.23

Dr. Kyle Gillett: Tools for Hormone Optimization in Males

Dr. Huberman welcomes Dr. Kyle Gillett, MD, a dual board-​​certified physician specializing in family medicine and obesity medicine. They discuss optimizing male hormones using nutrition, behavior, exercise, and supplementation. The conversation covers hormone levels during puberty and aging, bloodwork monitoring, and the impact of hormone health on fertility, libido, hair loss, and prostate health. They also explore prescription hormone therapies, biomarker monitoring, and optimizing synergistic hormones for overall well-​​being and longevity.

Key Takeaways

High level takeaways from the episode.

Entering puberty early can decrease adult height.

Increase in childhood obesity leads to earlier onset of puberty in both males and females.

Lifting heavy weights does not stunt growth. Dirty bulking (eating excess calories to acquire muscle and fat) can stunt growth through two mechanisms:

  • Excess body fat can lead to early puberty, which can limit adult height
  • Excess body fat can lead to insulin resistance, which can negatively affect growth hormone levels

Young males should avoid “dirty bulking” and focus on bodyweight exercises and weight training

  • Avoid rapid weight gain, to reach maximum height and avoid laying down excess body fat cells

Blood work should be done as early as possible to monitor hormone levels and overall health

  • For healthy children, blood work can be done during later tanner stages (4 and 5)
  • If concerned with stature or height, get blood work done earlier

Key things to look for in blood work:

  • Testosterone and sex hormone binding globulin (SHBG) or free testosterone
  • Balance between high enough free DHT and high enough total DHT

Blood work should be done twice a year for optimal monitoring and evaluation by a physician.

Ketamine is being explored as a treatment for depression: may increase neuroplasticity, and make depression not feel as heavy, separate from grief and other emotions. Recommended to have psychiatrist guiding experience.

Protocols

Science-​​based tools and supplements that push the needle.

Optimizing Growth Hormone Release

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Supplements for Optimizing Testosterone and Estrogen

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Supplements for Thyroid Health

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Source

We recommend using this distillation as a supplemental resource to the source material.

  • Dr. Kyle Gillett: Tools for Hormone Optimization in Males

    Huberman Lab #102

    Dr. Huberman and Dr. Kyle Gillett, MD, discuss optimizing male hormones through nutrition, exercise, behavior, and supplementation, covering puberty, aging, bloodwork, fertility, libido, hair loss, prostate health, prescription hormone therapies, biomarker monitoring, and synergistic hormone optimization for well-​​being and longevity.

Full Notes

Support the Podcast