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Last Updated: 16.05.23

Effects of Cannabis on Brain & Body

In this episode, Dr. Huberman explains cannabis (aka marijuana), including the biological mechanisms underlying its effects on the mind and body, its known medical applications, its impact on libido, creativity, hunger, hormones, as well as adverse its health consequences.


We recommend using this distillation as a supplemental resource to the source material.

  • Effects of Cannabis On Brain & Body

    Huberman Lab Podcast #92

    This episode explains the biological mechanisms of cannabis, risks associated, negative health effects, benefits, and impact on creativity, libido, and more.

Key Takeaways

High level takeaways from the episode.

Do not use cannabis or CBD during pregnancy or breastfeeding — CB1 receptors are an integral part of neural development, present in the newborn and the fetus.

Chronic use of cannabis in 16–24 year olds leads to a higher likelihood of developing depression + anxiety later in life, because the brain is still developing. 4x greater risk of psychosis for those with predisposition to bipolar or schizophrenia.

For those who start using cannabis at 12 or 14, gray matter thins — which is involved in planning & executing plans, organizing life. Some recovery of brain function can be restored by focusing on behaviors that increase brain health.

Even if cannabis use aids in depression or anxiety symptoms in the beginning, over 12 months, levels of anxiety and depression when not under the influence increase in chronic users (more than 2x/​​week).

Chronic cannabis use disrupts neural circuitry of speech: effects vocal effort and intensity, pronunciation of words and emphasis on particular words, less intonation and anunciation.

Cannabis may enhance creativity by increasing dopamine and divergent thinking, and reducing anxiety.

Generally speaking, smoking more than 2x/​​week increases prolactin — which lowers libido — and appears to reduce testosterone significantly. Edible cannabis doesn’t seem to have same effect, but research not extensive.

Positive medical uses of cannabis in adults:

  • Cancer (increase appetite, reduce nausea from chemotherapy)
  • Glaucoma (reduce intraocular pressure)
  • Pain reduction.

Smoking or vaping anything severely impairs the function of endothelial cells that make up the brain and body.


Science-​​based tools and supplements that push the needle.

Avoid Cannabis and CBD if Pregnant or Breastfeeding


Avoid Cannabis Before Age 25


Cannabis Benefits: Appetite, Nausea, Creativity, Pain


Full Notes


Brain Receptors

Endogenous Cannabinoids



Effects on Speech

Hormones & Libido

Women should avoid Cannabis and CBD while breastfeeding or pregnant.

Negative Health Effects

Positive Medical Uses of Cannabis in Adults