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Full Notes
Tim Ferriss’ Process for The Four Hour Body
- Explored new, very old, and orphaned ideas
- Interviewed experts in various fields
- Asked about what nerds are doing on weekends or at night
- Asked about what rich people are doing now that might become widespread in the future
- Looked for areas where people were cobbling together awkward solutions
- Studied extreme cases to inform the mean
- Examples: racehorses, bodybuilding, high-level athletes, billionaires, rich people
- Assumed practitioners would be ahead of scientific papers
- Coaches and athletes’ performance often lead to peer-reviewed exercise science papers, but with a lag time of at least 3–5 years
Tim Ferriss’ Approach to Structured Thinking
- Both structured and unstructured thinking
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Some exploration was a structured practice, while other ideas were allowed to naturally surface
Tim Ferriss on Writing and Routines -
Tim Ferriss has a habit of capturing almost everything in writing
- Wrote The Four Hour Body as a “choose your own adventure” book
- Used a program called Scrivener for gathering research and drafts
- Gathered data from various sources, including Evernote
- Writing schedule: 9 PM to 4 AM, when the rest of the world is inactive
- This schedule worked well for him, but it’s challenging for maintaining a social life
- Some creators need space and lack of distractions to be productive
- Writers often find ways to avoid writing
Anecdata and Case Studies
- Many discoveries begin as case studies or case histories
- Most knowledge about human memory comes from one patient, HM, who had his hippocampi removed for epilepsy
- Not all research will receive funding for randomized control trials (RCTs)
Self-Experimentation and Scientific Literacy
- Important to not fool oneself and be able to read studies well
- Becoming literate in scientific studies provides a significant life advantage
- Peter Attia’s “Studying the Studies” blog series is a helpful resource
BPC 157
- Gastric peptide synthesized for injection into tissue for healing or improvement
- Lacks published data, but has anecdotal evidence of healing injuries faster
- Unlikely to have a controlled trial due to lack of financial incentives and career risks for researchers
Supplement Fails
- Experimenting with supplements can lead to failures and negative side effects
- Example: Trans-resveratrol caused joint pain and was discontinued
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Example: Bulbine Natalensis spiked testosterone levels but caused a crash and testicular pain after 7–10 days of use
Supplement Fails and Experimental Fails -
Discussing the idea of a “Supplement Fails” podcast
- Importance of being cautious with injections and potential infections
Platelet-Rich Plasma (PRP)
- Can be useful for certain types of injury or repair
- Risks include potential infections from injections
Slow Carb Diet
- High adherence rate and effective for many people
- Can be done on a reasonable budget
- Includes the infamous “cheat day”
- Works well for maintaining energy levels and performance in various activities
30 Grams of Protein Within 30 Minutes of Waking
- Counterintuitive but effective for many people
- Helps with appetite suppression and thermic effect of food
- Can lead to a net decrease in daily calories consumed
Time Restricted Feeding and Intermittent Fasting
- Some people lose muscle mass when not done correctly
- Important to monitor body composition and hydration levels
- Fasting can be effective when done properly
Ketosis and Metabolic Psychiatry
- The impact of diet on mental health is becoming more widely recognized
- Specific diet protocols can be used to treat mental health issues
- The connection between mind and body is important to consider in overall health
Power of Places
- The role of places in personal and professional growth
- High-density areas can provide valuable networking opportunities
- Examples: New York, Los Angeles, San Francisco, Chicago, Ottawa (Shopify), Pittsburgh (Duolingo)
- Consider moving to a high-density area for a period of time to grow and build capabilities
Volunteering and Networking
- Volunteer at events with interesting speakers and attendees
- Be proactive and go above and beyond in your volunteering role
- Producers of events will notice your hard work and dedication
- This can lead to invitations to join meetings, plan future events, and recruit speakers
- Build your network by being professional, on time, and easy to work with
- High performers will notice and appreciate these qualities
In-Person Networking
- Focus on the uncrowded channel of in-person networking
- Attend conferences and interact with humans in the hallway
- Approach panelists and moderators after events
- Moderators are often overlooked and can provide valuable connections
- Be genuine and express your interests and goals
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This can lead to introductions and opportunities in your desired field
Building Networks and Asking Questions -
Approach networking by genuinely connecting with people
- Focus on developing deeper relationships rather than collecting contacts
- Avoid trying to connect with famous people for the sake of social validation
- Ask yourself important questions to examine your motivations
- Example: “If I could never talk about this, would I do it?”
- Collect and revisit powerful questions
- Questions can help with self-inquiry and personal growth
- Example: “What would you do if you knew you were going to fail?”
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Journaling can help refine the questions you ask yourself
- Helps to cross-examine and stress test your beliefs and certainties
Exploring Psychedelics
- Helps to cross-examine and stress test your beliefs and certainties
-
Tim Ferriss’ first experience with psychedelics
- During his undergraduate years at Princeton
- Initially a psychology major with a focus on neuroscience
- First tried mushrooms recreationally
- Consumed a large amount (over 5 grams)
- Experience was bizarre, nonlinear, and unlike anything he had experienced before
- Led to a curiosity about the compounds and their effects on the brain
- Wrote a paper in 1998 or 1999
- Examined potential similarities between REM sleep and LSD-25
- Looked at patterns of neural activity
- Professor Barry Jacobs
- Worked on serotonergic systems
- Studied cats, as they sleep a lot and are interesting to study
- Tim Ferriss’ interest in psychedelics
- Driven by the unknown and the potential for growth in understanding
- More interested in areas that baffle most people examining them
Animal Research in Neuroscience
- Tim Ferriss struggled with the idea of animal research
- Specifically, the process of injecting retroviruses into rats and then bleeding them to death to avoid bruising of the tissue
- Decided he couldn’t do it and transferred out of neuroscience
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Andrew Huberman’s laboratory
- Shutting down mouse work
- Prefers to work on humans, as they can give consent and house themselves
- Animal research is tough for any sentient being, but there is a place for it in scientific research
Personal Experience with Psychedelics
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Suffered from major depressive disorder and extended depressive episodes
- On average, three to four episodes a year, lasting a few weeks to a few months
- Noticed an afterglow effect from higher dose experiences with mushrooms (psilocybin)
- Antidepressant or mood-elevating effect lasting far longer than the half-life of the substance
- Had a scary experience that led to stopping the use of psychedelics
- Revisited the idea in 2012–2013 after witnessing the transformation of a girlfriend through Ayahuasca
- Approached psychedelics systematically with safeguards and proper supervision
- Personal outcome: from three to four depressive episodes per year to one every two years
Exploring Meditation and Psychedelics
- Started Transcendental Meditation ™ during a period of acute stress
- Described as a “warm bath for your mind” that helps with relaxation and anxiety
- Began examining how to approach taking psychedelics in a logical sequence with proper protections and safety assurances
- Took copious notes over the span of ten-plus years
Funding Psychedelic Research
- Initially funded early-stage science, such as Adam Ghazali’s lab at UCSF
- Research on software to attenuate or reverse age-related cognitive impairment
- Committed to funding psychedelic research once financially able
- Saw potential in the field due to limited funding and high leverage
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Crowdfunded for a Johns Hopkins pilot study on psilocybin for treatment-resistant depression
- No negative blowback, and support from others in the field
- Realized that the perception of psychedelics did not match the reality
- People want solutions for mental health issues, even if it involves psychedelics
Tim Ferriss on Psychedelics and Mental Health
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Tim Ferriss has been a strong advocate for mental health therapeutics, including psychedelics
- Believes they can challenge much of what we assume to be true about treating mental health
- Attracted to the field because it’s uncrowded and high-leverage
- Ferriss has funded various projects and initiatives related to psychedelics
- Crowdfunding for the Hopkins Treatment Resistant Depression Pilot study
- Ferris UC Berkeley Journalism Fellowship in partnership with Michael Pollan
- Provides funding to journalists focusing on psychedelics as their beat
- Aims to shape and inform national and international discourse on the topic
- Harvard Poplar: first dedicated team focused on law, policy, and regulation related to psychedelics from a legal perspective
- Developing curricula for Yale, Johns Hopkins, and NYU to train psychiatrists in administering psychedelic-assisted therapies
Future of Psychedelic Therapies
- MDMA-assisted psychotherapy for the treatment of trauma is likely to become legal within the next 12–24 months in the US
- Due to the efforts of Maps.org, Rick Doblin, and others
- Important for the future of other psychedelic therapies, such as psilocybin for alcohol use disorder and major depressive disorder
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Ferriss emphasizes the importance of breaking down the process of changing national policy and reclassification of compounds
- Focus on the critical few and execute the plan in a logical sequence
- Avoid trying to do everything at once, which is a common weakness in the psychedelic ecosystem
Sisa Foundation Outcomes
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Using the same filters and approach as in startup record
- Looking for high leverage, uncrowded bets with limited downside
Transcranial Magnetic Stimulation (TMS)
- Non-invasive technique
- Can inhibit specific brain areas or stimulate at particular frequencies
- Enhance neuroplasticity
- Potential synergistic effect with psychedelics
- Monotherapy for depression, anxiety, substance use disorders
Metabolic Psychiatry
- Ketosis and ketogenic diet effective for some patients with chaotic conditions
- Interested in off-the-beaten-path tools that raise interesting questions
Meditation Practices
- Tim Ferriss does 10–20 minutes in the morning
- Concentration practice with a mantra or guided meditation (e.g., Waking Up app by Sam Harris)
- Spending time in silence, in nature, without distractions
- Extended water fasts in nature
Reentry After Time in Nature
- Pre-during-post approach
- Putting better systems in place before going off the grid
- Ensuring the house doesn’t catch on fire while away
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Implementing policies and rules in advance
Nature Retreats and Mental Health -
Nature retreats can help with mental health and well-being
- Provides a break from daily routine and stressors
- Allows for reflection and recovery
- Importance of easing back into daily routine after a retreat
- Avoid jumping straight back into a busy schedule
- Gradually reintegrate to maintain benefits from the retreat
Mentors and Learning from Others
- Mentors can be friends or people you admire
- Can be older or younger than you
- Important to choose people who embody areas of life you want to emulate
- Learning from others can come from various sources
- Teachers, coaches, or even strangers
- Requires self-awareness to know what areas to work on
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Example: Matt Mullenweg, founder of Automatic
- Exemplifies a calm temperament in chaotic situations
- Can serve as a mentor for maintaining emotional balance
Balancing Inward and Outward Learning
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Inward learning: meditation, nature, psychedelics
- Outward learning: learning from others, paying attention to others
- Balancing mind allocation across the year and day
Yearly Mind Allocation
- Past Year Review (PYR) on New Year’s Eve
- Analyze positive and negative experiences from the past year
- Create a “do more of” and “do less of” list
- Schedule important activities for the upcoming year
Weekly Mind Allocation
- Create a weekly rhythm to focus on certain types of tasks
- Monday: administration tasks
- Schedule physical activity after lunch
- Avoid cognitive switching and task switching
Social Media and Time Management
- Time spent on social media can be detrimental to productivity
- Deleting social media apps from the phone can help with time management
- Importance of scheduling time for important activities
Cockpunch: A Creative Project
- Aims to make the creator less precious about their brand
- An investment in long-term mental health and career flexibility
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Experiment with fiction writing
Tim Ferriss’ Cockpunch Project -
Started as a way to explore creativity and fundraise for early-stage science
- Combines interests in Web Three, NFTs, illustration, and visual arts
- Raised almost $2 million for science, distributed through grants
- Project led to reconnecting with old friends, learning new technologies, and exercising creative muscles
- The Legend of Cockpunch: a fantasy world-building exercise in the form of short stories
- Takes place in the realm of Varlata
- Narrated by the 7th Scribe
- Features eight primary houses with anthropomorphized rooster characters
- The Great Games: a combat competition between the houses, nicknamed “Cockpunch”
- Project brings Tim Ferriss peace, contentment, and delight
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Demonstrates the importance of giving oneself permission to explore and challenge the impossible
Psychedelic Research and Funding -
Rapidly changing field of early-stage psychedelic science
- Foundations doing good work in the field:
- Riversticks Foundation
- Beckley Foundation
- Scise Foundation
- Scise Foundation supports various projects, from basic science to sophisticated imaging studies and phase three trials for MDMA-assisted psychotherapy
Tim Ferriss on Sharing Personal Struggles
- Discussed near-suicide in college
- Dark secret, never told parents or close friends
- Decided to write about it after an encounter with a young man who lost his brother to suicide
- Realized sharing his story could help others struggling with mental health
- Importance of discussing mental health and personal tribulations
- Helps others feel less alone in their struggles
- Encourages open conversation and support
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