Protocols
Science-based tools and supplements that push the needle.
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Full Notes
Water: A Controversial Topic
- Water is essential for life, but opinions on its consumption vary
- Two camps:
- Tap water is safe (with some filtering)
- Tap water is unsafe, relying on alternatives like reverse osmosis, deuterium-depleted, or hydrogen-rich water
Tap Water Safety and Filtering
- Addressing tap water safety and filtering options
- Tools to determine tap water safety and filtering needs
- Concerns about fluoride and endocrine disruptors in tap water
Alternative Water Types
- Distilled water
- Reverse osmosis water
- Spring water
- Deuterium-depleted water
- High pH water
pH and Water Absorption
- pH of water affects absorption and impact on biological systems
- Importance of pH, but not for reasons commonly believed
Water Temperature and Absorption
- Temperature of water affects rate of absorption and impact on cells, tissues, and organs
- Importance of water temperature for health
Hydration: When and How
- Best practices for hydrating the body
Deliberate Cold Exposure for Fat Loss
- Cold exposure can benefit fat loss, metabolism, and mood
- Study on cold exposure and fat loss in soldiers
- 49 subjects, both male and female, aged 19–30
- One session per week of cold immersion (3°C/37.4°F) for 2 minutes
- Minimum of five cold showers per week (10°C/50°F) for 30 seconds
- Subjects warmed up naturally after cold exposure
- Results showed substantial fat loss, especially around the abdomen
-
Ease into cold exposure to avoid shock
Deliberate Cold Exposure Benefits -
Deliberate cold exposure protocol used in a study:
- 2 minutes of cold immersion at 3°C (37.5°F) + 5 cold showers per week, 2 minutes long at 10°C (50°F)
- Statistically significant positive changes observed in the study:
- Improved mood, anxiety regulation, and sexual satisfaction
- Possibly due to increased testosterone levels in both men and women
- Reduction in waist circumference and 5.5% reduction in abdominal fat in men
- Unclear why no reduction observed in women, possibly due to differences in fat storage and metabolism
- Improved mood, anxiety regulation, and sexual satisfaction
- Deliberate cold exposure can improve mood and well-being through increased catecholamines
- Impact on metabolism has been controversial, but this study suggests it can lead to weight loss and body fat loss
Cold Exposure Protocol
- 2 minutes of deliberate cold exposure through water immersion up to the neck
- 5 times a week, 30 seconds each of deliberate cold exposure through cold showers
- Focus on head, back of the neck, and upper back where brown fat stores are concentrated
- Cold exposure to these regions triggers adaptation of increased brown fat stores and mitochondria
Caloric Deficit and Cold Exposure
- Calories in, calories out still applies for fat loss
- Deliberate cold exposure may elevate metabolism, increasing the calories out component
- Study participants who lost body fat were likely in a caloric deficit due to elevated metabolism from cold exposure
Water Molecule Structure
- Water is H2O: two hydrogens and one oxygen
- Physical arrangement of hydrogens and oxygen is important for water’s function
-
Water molecule is polarized, allowing them to bind to one another through positive and negative attractions
Understanding Water Molecules and Their Properties -
Water molecules consist of two hydrogen atoms and one oxygen atom (H2O)
- Can be visualized as a peace symbol
- Individual water molecules can bind to one another through covalent bonds
- Covalent bonds are relatively weak but strong enough to maintain some structure
- Temperature is a strong determinant of the arrangement of water molecules and the spacing between their bonds
- Water can exist in at least three forms: liquid, gas, and solid
- Liquid: the most common form we think of when we think of water
- Gas: steam, which occurs when water is heated up
- Solid: ice, which forms when water is cooled down
- Ice is less dense than liquid water, causing it to float
- This property is essential for life on Earth and the functioning of our cells
- Water can exist in at least three forms: liquid, gas, and solid
Surface Tension and Density of Water
- Water has a certain level of surface tension
- Thin layer of water molecules at the surface is more dense than the water at deeper depths
- Most objects, including humans, are more dense than water and will sink
The Fourth Phase of Water: Structured Water
- Structured water is a unique configuration of water molecules
- Positives and positives attract and form bonds stronger than typical bonds between water molecules
- Some scientists believe that within the body, organelles of our cells act as a substrate for water to exist in this fourth form
- This has led to a niche industry of proponents of consuming structured water
- The relevance of structured water to the biological function of our body is still debated
Key Points to Remember
- Water molecules (H2O) can bind to one another through covalent bonds
- Temperature affects the arrangement and spacing of water molecules
- Water can exist in at least three forms: liquid, gas, and solid (ice)
- Ice is less dense than liquid water, allowing it to float
- Water has surface tension and varying density
- Structured water is a debated fourth phase of water with unique properties
Surface Tension and Water Properties
- Surface tension of water may relate to standard bonds or a debated fourth phase
- Water can bead up or aggregate on surfaces like wax paper or glass
- Due to covalent bonds between water molecules
- Water can also bind to certain surfaces
- Bonds between water in solid form (ice) and surfaces are stronger than bonds between water molecules or water and surfaces in warmer states
Water in the Human Body
- Water molecules are versatile and can bind to each other and different surfaces
- Temperature and pH of water are important determinants of how water is used by cells
- Human body is 70% to 90% water, depending on definition and context
- Water is essential for life and health
Water as a Solvent
- Water can dissolve substances like sugar or salt due to their hydrophilic nature
- Hydrophilic substances interact with hydrogen and oxygen in water molecules
- Water is one of the best solvents, even better than acid for dissolving many solids
- Hydrophobic substances, like lipids, do not dissolve well in water
- Temperature and pH impact the tendency of hydrophilic and hydrophobic substances to dissolve in water
Water in Cells
- All cells in the body require water to function properly
- Water can enter cells through drinking or breathing in humid air
- Two main ways water can access cells:
- Directly through cell membrane
- Through specialized channels or transporters
- Temperature and pH of water can impact cellular function and overall health
Types of Water and Cellular Function
- Different types of water (e.g., pH, distilled, reverse osmosis) can impact cell function
- Some types of water may be beneficial or harmful to cells
-
Understanding the physics, chemistry, and biology of water is essential to understanding its role in health and disease
Value of Elevated pH Water -
Accelerated absorption
- Growing evidence of adjusting immune system cell function
- Reduces certain inflammatory responses
- Not necessary to buy expensive water for maximum benefit
Increasing Water Absorption Rate
- Temperature
- Filtering water
- Other tricks to be discussed later
Hydration and Cognitive Function
- Proper hydration of brain cells can greatly enhance cognitive function
Water in Cells
- Two ways water gets into cells: diffusion and movement through aquaporin channels
- Temperature and pH of water affect the arrangement of water molecules
- Once inside cells, water is incorporated into proteins and organelles
- Many biological processes involve the bonding or lack of bonding between water molecules and proteins
Reactive Oxygen Species (ROS) and Antioxidants
- ROS, also known as free radicals, can damage cells
- Antioxidants help repair bonds between cells and prevent damage
- Water can act as an antioxidant, provided it bonds correctly and is in the proper amounts and rates
Impact of Water on Health, Disease, and Repair
- Temperature, pH, and amount of water consumed can impact the health of cells, tissues, and organs
Determining How Much Water to Drink
- Many studies show that even slight dehydration negatively impacts brain and body function
- Endurance, strength, and cognitive performance are all impaired when dehydrated
- Measuring dehydration through skin elasticity and fingernail color change tests
Following Natural Thirst and Urine Color
- Can we rely on natural thirst to determine hydration needs?
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Does urine color provide an indication of hydration levels?
Dehydration and Fluid Intake -
Dehydration indicators, such as skin elasticity and nail bed color, are not perfect measures
- Most statements about dehydration affecting cognitive or physical performance are based on reductions in water intake, not direct measures of hydration
- Fluid requirements are different for each individual and can vary based on age, body composition, and other factors
Daily Fluid Intake Recommendations
- For the first 10 hours of the day, consume on average 8oz (236ml) of fluid per hour
- This translates to 80oz (2.4L) of fluid for the first 10 hours of the day
- Fluid intake does not have to be consistent every hour; it can be ingested in larger amounts at different times
- Fluid requirements are different during the later evening and nighttime
- These recommendations are for people at rest, not exercising, and not in extremely hot environments
Fluid Intake During Exercise
- The Galpin equation: Body weight in pounds divided by 30 equals the number of ounces of fluid to consume on average every 15–20 minutes while exercising
- For the metric system: 2ml of fluid per kilogram of body weight every 15–20 minutes on average
- Hydration prior to exercise is also important; following the daily fluid intake recommendations should establish a good baseline of hydration before exercise
- Fluid intake during exercise can replace the baseline fluid intake for that hour
Exercising in Heated Environments or Sweating More
- Fluid intake may need to be adjusted for those exercising in heated environments or for individuals who tend to sweat more
-
Sweating is an adaptation that can be improved by spending more time in hot environments or saunas
Adapting to Sweating and Fluid Intake -
Sweating is an adaptation that helps cool the body
- Exercising in hotter or more humid temperatures can improve sweating ability
- Fluid intake should be increased by 50% to 100% in hot environments or during heavy sweating
- In a sauna, consume 8–16oz (240–500ml) of fluid for every 20–30 minutes
Dehydration and Thirst
- Thirst is a reasonable guide for dehydration, but it doesn’t always keep up with the body’s level of dehydration
- Feeling parched, having a dry throat, or being very thirsty are signs of dehydration
- Consume 16oz (500ml) of fluid per hour while feeling parched
- Avoid caffeine or diuretics when dehydrated; consume fluids with electrolytes or a pinch of salt
Hydration and Cognitive/Physical Performance
- Even slight dehydration can impair cognitive and physical performance, causing fatigue and brain fog
- Proper hydration can enhance focus, energy, and overall performance
- Fluid intake triggers elevated levels of alertness through the sympathetic arm of the autonomic nervous system
- Sufficient hydration is signaled to the brain through mechanical and chemical signals, leading to increased alertness and performance
Circadian Rhythms and Kidney Function
- Kidney function is strongly regulated by circadian clock genes
- For the first 10 hours after waking, the kidney filters fluid at a rapid rate
- After 10 hours, kidney function starts to reduce, becoming less efficient at filtering fluid
- Reduced kidney function at night is beneficial to prevent excessive fluid filtration during sleep
Fluid Intake Recommendations
- Consume 8oz (240ml) of fluid per hour for the first 10 hours of the day after waking
- Increase fluid intake during exercise, hot environments, or heavy sweating
- Monitor thirst and dehydration signs to adjust fluid intake accordingly
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Consider electrolyte drinks or adding a pinch of salt to water for optimal hydration
Reducing Nighttime Waking to Urinate -
Common concern: waking up in the middle of the night to urinate
- To reduce nighttime waking to urinate, do the following:
- Hydrate sufficiently during the day
- Reduce fluid intake at night, provided you hydrated enough during the day
- Consume fluids slowly in the evening, as the rate of fluid ingestion affects how quickly it is excreted
- Most people can reduce fluid intake to about 5–8oz in the later part of the day and still avoid excessive nighttime waking
Tap Water Concerns
- Research on tap water reveals a grim picture of contaminants
- Tap water often contains endocrine disruptors, hormone disruptors, and disinfection byproducts (DBPs)
- DBPs can cause endocrine disruption, negatively impacting reproductive health, ovarian function, and spermatogenesis
- Fluoride in drinking water is of particular concern for the thyroid hormone system
- Thyroid hormone impacts metabolism, energy levels, mood, sleep, reproduction, bone health, and tissue health
- A 2018 study found that even 0.5 milligrams of fluoride per liter of water can disrupt thyroid function
Checking Your Tap Water
- Look up your zip code or municipal area code online to find information on your tap water’s contents
- Focus on fluoride levels, as they can impact thyroid function
- Aim for fluoride concentrations below 0.5 milligrams per liter
-
Consider filtering your drinking water to reduce contaminants and improve overall health
Filtering Tap Water for Health -
Health status can determine the need for filtering tap water
- Healthy individuals may not need to filter water, but it’s still recommended
- Those with health concerns should filter tap water due to disinfectant byproducts and fluoride levels
- Different filtering options available:
- Brita-type filters (carbon filters) — effective for disinfectant byproducts, not as effective for fluoride
- At-home water filters that remove fluoride — various price ranges, search online for options
- Clearly Filtered Water Pitcher with Affinity Filtration — around $80, removes fluoride, lead, BPAs, glyphosates, hormones, etc.
- Whole house water filters — $2,000 or more, filters water for the entire house
- Intermediate systems — $200 to $500, e.g. Berkeley filter system, countertop units that filter large volumes of water
- Filtration mechanisms:
- Mechanical filtration — physically constrains molecules by size
- Chemical filtration — filters treated with chemicals to neutralize certain contaminants
- Zero-cost option for those who can’t afford filters:
- Let tap water sit in an uncapped container at room temperature for a half day or more
- Pour off top two-thirds of water into another container and consume from there
- This method removes some contaminants, especially those from pipes
Testing Drinking Water
- Some individuals may want to test their drinking water for contaminants, hard metals, magnesium, and calcium levels
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Various methods and kits available for testing drinking water quality
Drinking Water Quality and Health -
Importance of water quality for overall health
- Tap water can contain contaminants, such as disinfectant byproducts and fluoride
- Filtration systems can help improve tap water quality
Low-Cost Water Filtration Options
- Lower cost filters can still provide safe drinking water
- Experiment with molecular hydrogen water, which has to do with magnesium, calcium, and pH levels
Hard Water vs. Soft Water
- Hard water contains more magnesium and calcium
- Studies show an association between higher magnesium content in water and lower cardiovascular mortality
- Hard water may not taste as good but can be better for health
Magnesium, Calcium, and pH Levels
- Higher magnesium and calcium content in water increases its pH
- Higher pH water (7.9 to 9.2) is more readily absorbed and can have favorable health effects
- Lower pH water is not necessarily bad, but higher pH water can be beneficial
Boiling Water and Temperature
- Boiling water can decontaminate some contaminants, but not all
- Some contaminants can be made worse by heating water
- Filtration systems are recommended in addition to boiling
- Temperature of water consumed is a personal preference and does not significantly impact absorption
Types of Water
- Distilled water has magnesium and calcium removed, not recommended for regular consumption
- Reverse osmosis water has contaminants removed while ideally retaining magnesium and calcium
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Reverse Osmosis Water -
Evidence suggests reverse osmosis water can deprive water of magnesium and calcium
- Ensure adequate magnesium intake if using reverse osmosis filters
- Reverse osmosis filters can be expensive and require frequent filter changes
- Some people prefer the taste of reverse osmosis water, describing it as smoother and more energizing
- No direct studies on the subjective sensation of water and its health effects
Hydrogen Water and Other Unique Categories of Water
- Hydrogen-enriched water, electrolyzed reduced water, and deuterium-depleted water all have higher pH levels than other forms of water
- Higher pH levels are more readily used by the body’s cells, leading to more efficient hydration
- Consuming specialized forms of water usually means the water is filtered of disinfectant byproducts and fluoride
- Cleaner water can indirectly explain some health benefits
- Hydrogen-enriched water can be created by dissolving magnesium tablets in water
- Consume within 5–15 minutes after the tablet dissolves for best results
Health Benefits of Hydrogen-Enriched Water
- Study: “Hydrogen Rich Water Reduces Inflammatory Responses and Prevents Apoptosis of Peripheral Blood Cells in Healthy Adults”
- Drinking 1.5 liters of hydrogen-enriched water per day for four weeks showed reduced inflammation and improved biological antioxidant potential in certain cell types
- Improvements were only observed in individuals older than 30 years old
- Subjective experience of increased energy and feeling better when drinking hydrogen-enriched water
- Could be due to placebo effect
Water, Hydration, and Health
- Importance of proper hydration for cognitive focus, physical ability, and overall health
- Reduction in blood pressure, improvements in appetite, mood, and focus with proper hydration
Tap Water and Contaminants
- Contaminants in tap water exist in all regions of the world
- Quality of tap water affected by external source, pipes in building/apartment, and faucet filter
- Importance of cleaning faucet filters to reduce contaminants
How Much Water to Drink
- Galpin equation for water consumption during exercise
- 8oz (240ml) of water per hour for 10 hours from waking until post waking on average
- Averages, not strict hourly consumption
Hydrogen-Enriched Water
- Can be beneficial if tap water lacks sufficient magnesium
- Dissolvable magnesium tablets can create hydrogen-rich water
- Inexpensive alternative to prepackaged hydrogen water
- Use once or twice a day, not in all water consumed
Structured Water
- Controversial topic, no clear evidence of benefits in peer-reviewed scientific literature
- Expensive at-home systems to create structured water
- Potential for further exploration of biological effects
- Open question, more data needed to determine benefits
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